Usefulness of PET-CT for Invasive Fungal Infection

The goal of this national multicenter prospective cohort study is to learn about the added value of 18F-FDG (18F-2-fluoro-2-deoxy-D-glucose) PET-CT in invasive fungal disease management. The main questions it aims to answer are: 1. Does the use of 18F-FDG PET-CT allow a better characterization of invasive fungal infection (IFI) (performance) compared to the exclusive use of conventional radiological studies in terms of extension/staging and monitoring of response/follow-up ? 2. Does the systematic and protocolized use of 18F-FDG PET-CT in IFI allow a better management of patients with IFI and increase the prognostic value of the initial evaluation? Participants will undergo systematically a 18F-FDG PET-CT as part of the work-up of their invasive fungal disease. Researchers will compare the performance of 18F-FDG PET-CT with standard management without 18F-FDG PET-CT to see if adds value (diagnostic, prognostic, and changes in management).

NCT Number	NCT05688592
Lead Sponsor	Puerta de Hierro University Hospital Collaborators: Gilead Sciences
Conditions	Invasive Fungal Infections
Enrollment	224 participants
Start Date	2023-04-27
Primary Completion	2024-10-31 (estimated)
Study Completion	2024-12-01 (estimated)
Updated on ClinicalTrials.gov	2024-11-06