Photopheresis in Early-stage Mycosis Fungoides

The purpose of this study is to determine whether photopheresis therapy can be used to improve the clinical course of early stage cutaneous T-cell lymphoma (CTCL). Currently, photopheresis is performed as a palliative treatment for late stage CTCL. However, recent studies have demonstrated that patients with early stage CTCL may have markers in their blood which were previously observed primarily in late stage disease, such as clonal T cell populations. Considering these findings, the study aims to investigate whether photopheresis therapy may be used earlier in the disease course to produce a clinical response.

NCT Number	NCT05680558
Lead Sponsor	Columbia University Collaborators: Mallinckrodt, Inc.
Conditions	Cutaneous T Cell Lymphoma, Mycosis Fungoides
Enrollment	74 participants
Start Date	2021-05-08
Primary Completion	2027-03 (estimated)
Study Completion	2028-07 (estimated)
Updated on ClinicalTrials.gov	2026-04-27