Tissue Destruction and Healing in Celiac Disease

The purpose of this clinical study is to learn more about celiac disease pathogenesis and clinical symptoms. In particular, this study will examine the interactions between biological factors such as, intestinal epithelial cells, microbiota, immune system, genetics, and gluten and their effect on celiac disease clinical symptoms, and severity of tissue destruction and its ability to heal in individuals with celiac disease. Information collected in the study will help researchers to generate better resources to advance celiac disease patient care.

NCT Number	NCT05680012
Lead Sponsor	University of Chicago Collaborators: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Mayo Clinic, California Institute of Technology
Conditions	Celiac Disease
Enrollment	220 participants
Start Date	2023-07-14
Primary Completion	2027-05-01 (estimated)
Study Completion	2027-07-01 (estimated)
Updated on ClinicalTrials.gov	2026-07-28