Leveraging Regulatory Flexibility for Methadone Take-Home Dosing to Improve Retention in Treatment for Opioid Use Disorder

Using a stepped-wedge randomized controlled trial, the study will test whether a clinic-level multidimensional intervention conducted in 36 opioid treatment programs (OTPs) will improve clinical decision making, regulatory confusion, legal liability concerns, capacity for clinical practice change, and financial barriers to take- home dosing (THD) for methadone as compared to treatment as usual.

NCT Number	NCT05675735
Lead Sponsor	NYU Langone Health Collaborators: National Institutes of Health (NIH)
Conditions	Problems Related to Social Environment
Enrollment	318 participants
Start Date	2023-01-27
Primary Completion	2026-09-01 (estimated)
Study Completion	2027-08-31 (estimated)
Updated on ClinicalTrials.gov	2026-08-12