Clinical Trial

Confocal Laser Endomicroscopy Based Diet in Functional Dyspepsia

Study acronym: CLEFD
Unknown
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Record status
This record was last updated July 3, 2024 (before its estimated July 31, 2025 completion). Its status may not reflect the trial's current state.
Summary
After a thorough baseline evaluation, functional dyspepsia (FD) patients will be exposed to nutrients while undergoing confocal laser endomicroscopy (CLE). Patients presenting an acute mucosal reaction upon nutrient exposure will be instructed to exclude their respective trigger nutrient or a nutrient without mucosal reaction (=sham diet) from their diet for 4 weeks in a randomized, blinded crossover fashion. The aim of the trial is to assess the symptomatic response to the targeted diet and further elucidate mechanisms underlying the acute mucosal reactions observed in CLE upon nutrient exposure.
Protocol Amendment History 1 change
critical Trial status changed: Recruiting → Unknown 2026-08-02
Trial Details
NCT Number NCT05666154
Lead Sponsor Universitaire Ziekenhuizen KU Leuven
Conditions Functional Dyspepsia
Enrollment 65 participants
Start Date 2021-12-05
Primary Completion 2025-07-31 (estimated)
Study Completion 2025-08-31 (estimated)
Updated on ClinicalTrials.gov 2024-07-03