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Brain Controlled Spinal Cord Stimulation in Participants With Cervical Spinal Cord Injury for Upper Limb Rehabilitation

Study acronym: UP2
StatusRecruiting
PhaseNot applicable
Started
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Record History

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  1. Primary completion date: Mar 31, 2025 to Dec 31, 2026
    • Study completion date: Jul 2025 to Dec 31, 2026
    v3
  2. Trial status: Not Yet Recruiting to Recruitingv2 Show 4 more changesShow less
    • Study sites: 0 to 1
    • Study completion date: Mar 31, 2025 to Jul 2025
    • Start date changed from estimate of Mar 1, 2023 to May 22, 2023
    • Eligibility criteria expanded, about 276 words
  3. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Cervical spinal cord stimulation can elicit arm and hand movements through recruitment of proprioceptive neurons in the dorsal roots. In participants with cervical spinal cord injury, the spare roots bellow the lesion can be used to reactivate motor function. Decoding of motor intentions can be achieved through implantable electrocorticography (ECoG) devices. In this study, the investigators will use an investigational system using ECoG signal recording over the motor cortex to drive muscle specific electrical epidural spinal cord stimulation (EES). The investigators will assess the safety and preliminary efficacy of this system in 3 participants.
Trial Details
NCT Number NCT05665998
Lead Sponsor Ecole Polytechnique Fédérale de Lausanne
Conditions
(from sponsor)		 Cervical Spinal Cord Injury, Tetraplegia
Related terms Quadriplegia
Enrollment 3 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov