Clinical Trial

Brain Controlled Spinal Cord Stimulation in Participants With Cervical Spinal Cord Injury for Upper Limb Rehabilitation

Study acronym: UP2
Recruiting
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Summary
Cervical spinal cord stimulation can elicit arm and hand movements through recruitment of proprioceptive neurons in the dorsal roots. In participants with cervical spinal cord injury, the spare roots bellow the lesion can be used to reactivate motor function. Decoding of motor intentions can be achieved through implantable electrocorticography (ECoG) devices. In this study, the investigators will use an investigational system using ECoG signal recording over the motor cortex to drive muscle specific electrical epidural spinal cord stimulation (EES). The investigators will assess the safety and preliminary efficacy of this system in 3 participants.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2022-12-22; most recent amendment 2026-04-20.
Status change: Not Yet Recruiting → Recruiting 2023-05-22
Trial Details
NCT Number NCT05665998
Lead Sponsor Ecole Polytechnique Fédérale de Lausanne
Conditions Cervical Spinal Cord Injury, Tetraplegia
Enrollment 3 participants
Start Date 2023-05-22
Primary Completion 2026-12-31 (estimated)
Study Completion 2026-12-31 (estimated)
Updated on ClinicalTrials.gov 2026-04-23