Neurobiological Markers of Treatment Response for Anxiety and OCD

Obsessive-compulsive disorder (OCD) and anxiety disorders are common and debilitating conditions which are often chronic when treatment is not provided. International guidelines recommend cognitive behavioral therapy (CBT) as the first-line treatment, and research has shown that CBT can be delivered over a concentrated period of time. The Bergen 4-Day Treatment (B4DT) is an exposure-based treatment which is delivered over four consecutive days. B4DT has been shown to induce rapid and long-lasting remission in around 70% of patients. This provides a platform for studying psychological and neurobiological changes associated with treatment response and non-response. The present study will investigate longitudinal changes in psychological measures and DNA methylation in patients who receive the B4DT, as well as a subset will also undergo multimodal brain imaging.

NCT Number	NCT05663489
Lead Sponsor	Haukeland University Hospital Collaborators: University of Oslo, Amsterdam UMC, location VUmc, University of North Carolina, Chapel Hill, Harvard Medical School (HMS and HSDM), University of Bergen, Oslo University Hospital
Conditions	Obsessive-Compulsive Disorder, Social Anxiety Disorder, Panic Disorder
Enrollment	500 participants
Start Date	2018-03-23
Primary Completion	2024-08-01 (estimated)
Study Completion	2027-12-11 (estimated)
Updated on ClinicalTrials.gov	2022-12-23