Clinical Trial

Vascular mEchanisms in, Stroke, dePression, dementiA, and deliRum: The VESPAR Project

Study acronym: VESPAR
Recruiting
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Summary
The goal of this observational study is to determine the feasibility of using integrated Transcranial Doppler Ultrasonography or Near Infrared Spectroscopy to detect changes in cerebral autoregulation and neurovascular coupling in healthy, stroke, dementia, depression and delirium populations. We also aim to: * Determine the optimal stimulus for neurovascular coupling * To derive sample size estimates for a future study * To develop a multilevel, multivariate model that can be applied to future datasets
Protocol Amendment History 5 amendments
This ClinicalTrials.gov record has been amended 5 times since 2022-12-13; most recent amendment 2025-11-28.
Status change: Not Yet Recruiting → Recruiting 2023-07-18
Trial Details
NCT Number NCT05649800
Lead Sponsor University of Leicester
Conditions Cognitive Dysfunction, Stroke, Dementia, Depression, Delirium
Enrollment 140 participants
Start Date 2023-03-17
Primary Completion 2025-11-26 (estimated)
Study Completion 2026-08-26 (estimated)
Updated on ClinicalTrials.gov 2025-12-01