Clinical Trial

The Relationship Between Inflammatory ARTritis and CArdiac DIseAse

Study acronym: ARTCADIA

Active, Not Recruiting

Record status

This record was last updated February 28, 2024 (before its estimated March 1, 2025 completion). Its status may not reflect the trial's current state.

Summary

The goal of this prospective cohort study is to investigate cardiac comorbidity in a random sample of approximately 1200 patients from a population of outpatients with rheumatoid arthritis and axial spondyloarthritis referred to collectively as inflammatory arthritis (IA). The main questions it aims to answer are: * Using conventional echocardiography, the investigators aim to determine the prevalence of overt and asymptomatic cardiac dysfunction in a large random sample of outpatients with IA. Cardiac dysfunction will be evaluated by echocardiography and cardiac biomarkers (NT-pro-BNP, hs-TNT and hs-CRP). * In patients without known heart disease: Using 2, 5 and 10 year follow-up, the investigators aim to examine if advanced echocardiography can be used to detect early signs of heart disease by investigating the clinical significance of adding deformation measures - alone and in combination with selected biomarkers - to conventional risk factors in the cardiac risk assessment of patients with IA Participants will undergo an echocardiographic examination in combination with a general health assessment including obtainment of cardiac biomarkers and a electrocardiogram. Using advanced echocardiography - Tissue Doppler Imaging, 2- dimensional speckle tracking echocardiography, 3D-echocardiography and 3-dimensional speckle tracking echocardiography - the investigators also aim to compare myocardial deformation parameters of patients with IA to a gender and age matched control group without IA from the Copenhagen City Heart Study.

Protocol Amendment History 2 amendments

This ClinicalTrials.gov record has been amended 2 times since 2022-12-02; most recent amendment 2024-02-27.

Status change: Recruiting → Active, Not Recruiting 2024-02-27

Trial Details

NCT Number	NCT05647577
Lead Sponsor	University Hospital, Gentofte, Copenhagen
Conditions	Inflammatory Arthritis, Rheumatoid Arthritis, Spondylitis, Ankylosing, Axial Spondyloarthritis, Spondyloarthritis, Heart Failure, Ischemic Heart Disease, Valvular Heart Disease +7 more
Enrollment	1,285 participants
Start Date	2021-01-01
Primary Completion	2025-03-01 (estimated)
Study Completion	2033-03-01 (estimated)
Updated on ClinicalTrials.gov	2024-02-28