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MAnagement of Systolic Blood Pressure During Thrombectomy by Endovascular Route for Acute Ischaemic STROKE

Study acronym: MASTERSTROKE
StatusActive, Not Recruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated January 5, 2026 (before its estimated January 31, 2026 completion). Its status may not reflect the trial's current state.

Record History

See every version on ClinicalTrials.gov ↗

  1. Re-verified, no change to tracked fieldsv7
  2. Trial status: Recruiting to Active, Not Recruiting
    • Primary completion date: Dec 31, 2025 to Jan 31, 2026
    • Study completion date: Dec 31, 2025 to Feb 28, 2026
    • Site details revised at 6 of 6 sites
    v6
  3. Primary completion date: Dec 31, 2024 to Dec 31, 2025
    • Study sites: 4 to 6
    • Study completion date: Jun 30, 2025 to Dec 31, 2025
    • Collaborators expanded, about 28 words
    v5
  4. Study sites: 2 to 4v4
  5. Primary completion date: Jun 30, 2024 to Dec 31, 2024
    • Study completion date: Dec 31, 2024 to Jun 30, 2025
    v3
  6. Interventions: Active Comparator: Augmented - Systolic Blood Pressure (SBP) at 170mmHg +/- 10 mmHg (Procedure) to Blood pressure management of Systolic Blood Pressure to maintain target range +/- 10 mmHg (Procedure)
    • Secondary endpoints: details revised at 2 of 5 entries
    • Study title shortened, about 3 words
    v2
  7. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Stroke is the third most common cause of death in New Zealand and is one of the leading causes of long-term disability at all ages. A life-saving clot retrieval procedure can save lives and prevent disability of patients with ischaemic stroke who get to hospital in time. In New Zealand, 90% of clot retrieval procedures are performed under general anaesthesia. Many anaesthetic drugs can affect blood pressure (BP) and blood flow within the brain. Increasing BP during the procedure could provide additional benefits in this devastating disease. A large trial is needed to investigate BP management during clot retrieval.
Trial Details
NCT Number NCT05645861
Lead Sponsor Auckland City Hospital
Collaborators: The Australian and New Zealand College of Anaesthetists (ANZCA), Neurological Foundation of New Zealand, The University of Queensland, Auckland Medical Research Foundation, Auckland Hospitals Research and Endowment Fund
Conditions
(from sponsor)		 Stroke, Embolus Cerebral, Blood Pressure
Related terms Intracranial Embolism, Stroke
Enrollment 550 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov