Clinical Trial

MAnagement of Systolic Blood Pressure During Thrombectomy by Endovascular Route for Acute Ischaemic STROKE

Study acronym: MASTERSTROKE
Active, Not Recruiting
View on ClinicalTrials.gov →
Record status
This record was last updated January 5, 2026 (before its estimated January 31, 2026 completion). Its status may not reflect the trial's current state.
Summary
Stroke is the third most common cause of death in New Zealand and is one of the leading causes of long-term disability at all ages. A life-saving clot retrieval procedure can save lives and prevent disability of patients with ischaemic stroke who get to hospital in time. In New Zealand, 90% of clot retrieval procedures are performed under general anaesthesia. Many anaesthetic drugs can affect blood pressure (BP) and blood flow within the brain. Increasing BP during the procedure could provide additional benefits in this devastating disease. A large trial is needed to investigate BP management during clot retrieval.
Protocol Amendment History 6 amendments
This ClinicalTrials.gov record has been amended 6 times since 2022-11-30; most recent amendment 2025-12-30.
Status change: Recruiting → Active, Not Recruiting 2025-12-15
Trial Details
NCT Number NCT05645861
Lead Sponsor Auckland City Hospital
Collaborators: The Australian and New Zealand College of Anaesthetists (ANZCA), Neurological Foundation of New Zealand, The University of Queensland, Auckland Medical Research Foundation, Auckland Hospitals Research and Endowment Fund
Conditions Stroke, Embolus Cerebral, Blood Pressure
Enrollment 550 participants
Start Date 2019-11-28
Primary Completion 2026-01-31 (estimated)
Study Completion 2026-02-28 (estimated)
Updated on ClinicalTrials.gov 2026-01-05