RESTORES Trial: RESToration Of Rehabilitative Function With Epidural Spinal Stimulation

Spinal Cord Injury (SCI), being a devastating diagnosis, has little to no recovery which leads to a long-standing of debilitating impairment for affected patients. The NNI Neurosurgery team, together with our collaborators, are expanding our recruitment from our pilot trial named RESTORES: RESToration of Rehabilitative function with Epidural Spinal Stimulation. This study aims to investigate the feasibility of electrical stimulation via a spinal cord stimulator (SCS), which will be implanted into the study subjects, and advanced robotic neurorehabilitation to aid in improving neurological function in patients diagnosed with chronic SCI. An additional 15 patients on top of the 3 ongoing patients, male and female participants, above the age of 21 who have been diagnosed with the condition for more than a year will be recruited for this study over a 2-year period. Rehab sessions will take place pre and post-surgical implant, assessing subject improvements

NCT Number	NCT05644171
Lead Sponsor	National Neuroscience Institute Collaborators: Agency for Science, Technology and Research, Tan Tock Seng Hospital
Conditions	Chronic Spinal Cord Injury
Enrollment	18 participants
Start Date	2022-12-19
Primary Completion	2030-12-30 (estimated)
Study Completion	2031-12-30 (estimated)
Updated on ClinicalTrials.gov	2026-01-26