Clinical Trial

Dupilumab Step-down Strategy to Maintain Remission in Adult and Adolescents Patients With Atopic Dermatitis

Study acronym: MADULO
Active, Not Recruiting Phase 4
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Summary
The goal of this clinical trial is to compare a step-down strategy of spacing dupilumab injections with a standard maintenance treatment in adolescents and adults with controlled Atopic dermatitis (AD) for at least six months. The impact of dosage reduction strategies will be assessed with an innovative primary endpoint: the area under the curve of the weekly ADCT assessment.
Protocol Amendment History 10 amendments
This ClinicalTrials.gov record has been amended 10 times since 2022-12-07; most recent amendment 2025-09-10.
Status change: Recruiting → Active, Not Recruiting 2025-09-10
Status change: Not Yet Recruiting → Recruiting 2023-03-09
Trial Details
NCT Number NCT05642208
Lead Sponsor Nantes University Hospital
Conditions Atopic Dermatitis, Eczema, Atopic
Enrollment 256 participants
Start Date 2023-03-08
Primary Completion 2026-09-08 (estimated)
Study Completion 2026-09-08 (estimated)
Updated on ClinicalTrials.gov 2025-09-11