Clinical Trial

Trauma Resuscitation With Low-Titer Group O Whole Blood or Products

Study acronym: TROOP
Recruiting Phase 3
View on ClinicalTrials.gov →
Summary
The goal of this clinical trial is to compare the effectiveness of unseparated whole blood (referred to as Low-Titer Group O Whole Blood) and the separate components of whole blood (including red cells, plasma, platelets, and cryoprecipitate) in critically injured patients who require large-volume blood transfusions.
Protocol Amendment History 7 amendments
This ClinicalTrials.gov record has been amended 7 times since 2022-11-28; most recent amendment 2025-08-15.
Status change: Not Yet Recruiting → Recruiting 2023-08-11
Trial Details
NCT Number NCT05638581
Lead Sponsor University of Alabama at Birmingham
Collaborators: National Heart, Lung, and Blood Institute (NHLBI), The University of Texas Health Science Center, Houston
Conditions Wounds and Injuries, Shock, Hemorrhagic
Enrollment 1,100 participants
Start Date 2023-07-27
Primary Completion 2026-12-31 (estimated)
Study Completion 2027-06-30 (estimated)
Updated on ClinicalTrials.gov 2026-08-11