Clinical Study Evaluating Safety of Pentoxifylline and Celecoxib in Patients With Grand-Mal Epilepsy Treated by Phenytoin Monotherapy

Epilepsy is a chronic neurological disorder affecting millions of people all over the world. Epileptic seizures are caused by abnormal synchronized electrical neuronal discharges that could be either focal or widespread. Pathogenesis of epilepsy involves multiple processes including genetics, oxidative stress, ion channels, neuroinflammation, and cellular damage through autophagy and apoptosis. Neuroinflammation is considered one of the most important factors contributing critically to epileptogenesis.

NCT Number	NCT05637086
Lead Sponsor	Mostafa Bahaa Collaborators: Tanta University, Principal Investigator Maha Ahmed Younis, PhD Pharmacy Practice Department- Horus University
Conditions	Epilepsy
Enrollment	90 participants
Start Date	2022-12-20
Primary Completion	2026-12-20 (estimated)
Study Completion	2027-11-20 (estimated)
Updated on ClinicalTrials.gov	2024-07-18