Anti-inflammatory Drugs and Serum Prostate-Specific Antigen Test

Prostate cancer is the most frequently diagnosed cancer in men in the Unites States. Nearly 1 million prostate biopsy procedures are performed in the United States annually and elevated prostate-specific antigen (PSA) level is the primary reason for prostate biopsy in \> 90% of cases. However, at the PSA levels which trigger prostate biopsy, often no cancer is found in prostate biopsy specimens. PSA test can be elevated due to reasons other than cancer such as inflammation or natural variation in the level. Investigators plan to treat men with elevated PSA level with over the counter anti-inflammatory medications (ibuprofen, naproxen) to see if the PSA level will decrease to an acceptable level.

NCT Number	NCT05629494
Lead Sponsor	Albany Medical College
Conditions	Prostate Cancer, Prostate Inflammation, PSA
Enrollment	198 participants
Start Date	2022-09-27
Primary Completion	2026-03-01 (estimated)
Study Completion	2026-12-01 (estimated)
Updated on ClinicalTrials.gov	2024-10-18