Clinical Trial

Efficacy of Azelastine and Mometasone Irrigation in Comparison to Nasal Sprays in Patients With Chronic Rhinitis

Recruiting Phase 4
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Record status
This record was last updated July 28, 2023 (before its estimated August 2025 completion). Its status may not reflect the trial's current state.
Summary
The goal of this clinical trial is to determine the best combination of drugs and drug delivery routes to treat surgically naive chronic rhinitis patients. The main question it aims to answer is: Do high volume, high pressure delivery mechanisms in nasal irrigation improve the efficacy of azelastine combined with nasal steroid mometasone as compared to the standard low pressure, low volume delivery mechanisms in nasal sprays? Subjects will complete six months of one of three medication regimens: 1. Saline irrigation followed by azelastine spray and mometasone spray 2. Mometasone saline irrigation 3. Azelastine saline irrigation combined with mometasone saline irrigation.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2022-11-15; most recent amendment 2023-07-25.
Status change: Not Yet Recruiting → Recruiting 2023-07-25
Trial Details
NCT Number NCT05626621
Lead Sponsor Endeavor Health
Conditions Chronic Rhinitis
Enrollment 81 participants
Start Date 2022-11-23
Primary Completion 2025-08 (estimated)
Study Completion 2026-08 (estimated)
Updated on ClinicalTrials.gov 2023-07-28