Clinical Trial

Low Dose Radiation as Bridging Therapy in Relapsed B-Cell Non-Hodgkin Lymphoma

Active, Not Recruiting Phase 1
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Summary
The goal of this clinical trial is to learn about treatment for people with B-cell lymphoma that did not respond to treatment or that has gotten worse after treatment. The aim of this trial is to answer the following questions: * If it is realistic to give people radiation treatment before they receive a chimeric antigen receptor (CAR) T-cell treatment for their cancer * If it is safe to give people radiation treatment before they receive a CAR T-cell treatment for their cancer
Protocol Amendment History 8 amendments
This ClinicalTrials.gov record has been amended 8 times since 2022-11-11; most recent amendment 2025-09-23.
Status change: Recruiting → Active, Not Recruiting 2025-09-23
Status change: Not Yet Recruiting → Recruiting 2023-05-04
Trial Details
NCT Number NCT05621096
Lead Sponsor University of Nebraska
Collaborators: Bristol-Myers Squibb
Conditions DLBCL - Diffuse Large B Cell Lymphoma, High-grade B-cell Lymphoma, Follicular Lymphoma, Mediastinal Large B-cell Lymphoma, Indolent B-Cell Non-Hodgkin Lymphoma, Relapsed Non-Hodgkin Lymphoma, Refractory Non-Hodgkin Lymphoma
Enrollment 33 participants
Start Date 2023-03-21
Primary Completion 2025-01-20 (estimated)
Study Completion 2027-09 (estimated)
Updated on ClinicalTrials.gov 2025-09-25