NotablePrimary and study completion pushed from Dec 15, 2025 to Dec 15, 2026
Eligibility criteria expanded, about 8 words
Secondary endpoints: details revised at 36 of 36 entries
Publications: details revised at 33 of 35 entries
MinorSecondary endpoints: details revised at 4 of 36 entriesv6
NotablePrimary and study completion dates: Dec 1, 2024 to Dec 15, 2025v5Show 7 more changesShow less
Start date: Dec 1, 2022 to Nov 1, 2023
Primary endpoints: 44 to 8
Enrollment target: 75 to 90
Interventions: Control (Device), spine TENS (Device), tVNS (Device) to Control (Device), tSCS (Device), tVNS (Device)
Eligibility criteria shortened, about 9 words
Secondary endpoints expanded, about 136 words
Study description revised
MinorRe-verified, no change to tracked fieldsv4
NotableTrial status: Not Yet Recruiting to Recruiting
Primary and study completion dates: Dec 1, 2023 to Dec 1, 2024
Primary endpoints: 37 to 44
Site details revised
v3
MinorRe-verified, no change to tracked fieldsv2
MinorStudy First Submitted
Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Upper limb impairment is present in more than 85% of people with stroke, which greatly affect the quality of life, social participation, and performance of daily activities of people with stroke. Previous study also revealed that 53.4% of people after stroke experienced cognitive impairment. Different cognitive domains might be affected following stroke, such as attention, memory, language, and orientation, and the problems with memory are often prominent. Yet, there is no effective treatment for the post-stroke cognitive impairment.
Transcutaneous spinal cord stimulation (tSCS) and transcutaneous vagus nerve stimulation (tVNS) are simple and non-invasive treatment to improve upper limb motor function and cognitive function. However, no existing studies have explored on the effects of tSCS and tVNS on cognitive function in people with stroke. Therefore, the purpose of this study is to evaluate the effectiveness of transcutaneous electrical nerve stimulation (TENS) on improving upper limb function and cognitive function in people with chronic stroke.