Clinical Trial

Proximal Internal Carotid Artery Acute Stroke Secondary to Tandem or Local Occlusion Thrombectomy Trial

Study acronym: PICASSO
Recruiting Phase 3
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Record status
This record was last updated December 17, 2025 (before its estimated March 8, 2026 completion). Its status may not reflect the trial's current state.
Summary
The primary objective is to establish the efficacy of intra-arterial (IA) mechanical thrombectomy (MT) with extracranial proximal carotid artery acute stenting versus non-stenting approaches in patients with acute ischemic stroke (AIS) from intracranial vessel occlusion (IVO) in the anterior circulation and have a proximal carotid occlusive disease (occlusion or severe stenosis).
Protocol Amendment History 7 amendments
This ClinicalTrials.gov record has been amended 7 times since 2022-11-02; most recent amendment 2025-12-11.
Trial Details
NCT Number NCT05611242
Lead Sponsor Mercy Health Ohio
Conditions Acute Ischemic Stroke
Enrollment 404 participants
Start Date 2024-05-08
Primary Completion 2026-03-08 (estimated)
Study Completion 2027-05-08 (estimated)
Updated on ClinicalTrials.gov 2025-12-17