Proximal Internal Carotid Artery Acute Stroke Secondary to Tandem or Local Occlusion Thrombectomy Trial

Study acronym: PICASSO
StatusRecruiting
PhasePhase 3
Started

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Trial flagged as At Risk
Primary completion moved at least 2 years later Mar 8, 2026 → Mar 8, 2028
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Record History

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  1. Primary completion pushed from Mar 8, 2026 to Mar 8, 2028 Show 4 more changesShow less
    • Trial sites expanded: 51 → 60 locations
    • Study completion pushed from May 8, 2027 to Dec 8, 2028
    • Eligibility criteria expanded, about 6 words
    • Publications: details revised at 1 of 1 entry
  2. Study sites: 48 to 51v8
  3. Study sites: 34 to 48v7
  4. Study sites: 20 to 34v6
  5. Study sites revised (20)v5
Show 3 earlier versionsHide 3 earlier versions
  1. Study sites: 6 to 20
    • Primary completion date: Mar 1, 2026 to Mar 8, 2026
    • Study completion date: May 1, 2026 to May 8, 2027
    • Start date changed from estimate of May 1, 2024 to May 8, 2024
    v4
  2. Start date: Nov 1, 2023 to May 1, 2024v3 Show 7 more changesShow less
    • Primary endpoint revised
    • Study sites: 1 to 6
    • Primary completion date: Nov 1, 2025 to Mar 1, 2026
    • Study completion date: Dec 1, 2025 to May 1, 2026
    • Interventions: Balloon Angioplasty (Procedure), EMBOGUARD Balloon Guide Catheter (Device), IV-Antiplatelet Drugs (Drug), MT+CAS with IV-AP (Procedure)… to MT+CAS with IV-AP (Procedure), MT+CAS with PO-AP (Procedure), MT+CAT with PO-AP (Procedure)
    • Eligibility criteria shortened, about 53 words
    • Study description shortened, about 95 words
  3. Start date: Nov 1, 2022 to Nov 1, 2023
    • Interventions: Antiplatelet Drug (Drug), EMBOGUARD Balloon Guide Catheter (Device), Intra-arterial Therapy (Procedure) to Balloon Angioplasty (Procedure), EMBOGUARD Balloon Guide Catheter (Device), IV-Antiplatelet Drugs (Drug), MT+CAS with IV-AP (Procedure)…
    • Eligibility criteria expanded, about 110 words
    • Study description expanded, about 29 words
    v2
  1. Study First Submitted
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Mercy Health Ohio
3 trials monitored
See 2 trials at risk
Stroke
3,537 trials monitored
See 161 trials at risk
The primary objective is to establish the efficacy of intra-arterial (IA) mechanical thrombectomy (MT) with extracranial proximal carotid artery acute stenting versus non-stenting approaches in patients with acute ischemic stroke (AIS) from intracranial vessel occlusion (IVO) in the anterior circulation and have a proximal carotid occlusive disease (occlusion or severe stenosis).
Trial Details
NCT Number NCT05611242
Lead Sponsor Mercy Health Ohio
Conditions
(from sponsor)		 Acute Ischemic Stroke
Related terms Ischemic Stroke, Stroke
Enrollment 404 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov