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Exercise to Improve Brain Health in Older African Americans

StatusRecruiting
PhasePhase 2
Started
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Record History

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  1. Re-verified, no change to tracked fieldsv8
  2. Primary completion date: May 2026 to Jun 1, 2027
    • Study completion date: May 2027 to Aug 31, 2027
    • Start date: Apr 11, 2023 to Apr 20, 2023
    v7
  3. Re-verified, no change to tracked fieldsv6
  4. Trial status: Enrolling by Invitation to Recruiting
    • Primary completion date: Mar 2027 to May 2026
    • Study completion date: Mar 2028 to May 2027
    • Site details revised
    v5
  5. Trial status: Recruiting to Enrolling by Invitation
    • Site details revised
    v4
Show 2 earlier versionsHide 2 earlier versions
  1. Trial status: Not Yet Recruiting to Recruiting
    • Start date changed from estimate of Mar 2023 to Apr 11, 2023
    • Site details revised
    v3
  2. Study description expanded, about 405 wordsv2
  1. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The goal of this clinical trial is to test the effects of different types of exercise on brain health and Alzheimer's risk in older African Americans. Specifically, the main question\[s\] it aims to answer are: * What is the effect of a Cardio-Dance Fitness (CDF) vs. a Strength, Flexibility, and Balance (SFB) intervention on a cognitive marker of Alzheimer's risk, generalization? * What is the effect of the CDF vs. SFB intervention on a fMRI biomarker of Alzheimer's, neural flexibility, and do improvements in neural flexibility mediate improvements in generalization? * Do ABCA7 genotypic variations moderate the efficacy of the CDF vs. SFB intervention for reducing Alzheimer's risk? Participants will undergo-- at baseline and post-test-- health assessments, cognitive tests, and structural and functional magnetic resonance imaging (fMRI), and a blood-draw to assess Alzheimer's risk biomarker levels.
Trial Details
NCT Number NCT05597124
Lead Sponsor Rutgers, The State University of New Jersey
Collaborators: Göteborg University, University of California, Irvine
Conditions
(from sponsor)		 Aging, Alzheimer Disease, Healthy Aging, Cognitive Change
Related terms Alzheimer Disease
Enrollment 280 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov