Investigation of the Distinct Mechanisms Involved in Inflammatory Resolution Between Healthy Men and Women

Important differences exist between sexes in incidence, disease patterns and outcomes in coronary artery disease that is not well understood. It is likely that key differences in the underlying biological mechanism, in particular in inflammatory responses, play a part in underpinning these differences. Previous evidence demonstrates that healthy females appear to be more adept at resolving inflammation compared to healthy males. Since inflammation is thought to be a key initiating phenomenon in coronary artery disease the investigators will examine the differences in inflammatory resolution between the sexes in healthy volunteers.

NCT Number	NCT05597098
Lead Sponsor	Queen Mary University of London
Conditions	Inflammation
Enrollment	34 participants
Start Date	2022-12-12
Primary Completion	2027-12-12 (estimated)
Study Completion	2027-12-12 (estimated)
Updated on ClinicalTrials.gov	2026-07-16