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Super-Rehab: a Novel Approach to Treat Atrial Fibrillation

Study acronym: SuRe-AF
StatusActive, Not Recruiting
PhaseNot applicable
Started2023-04-03
View on ClinicalTrials.gov ↗
Record status
This record was last updated August 12, 2025 (before its estimated November 30, 2025 completion). Its status may not reflect the trial's current state.

Amendment history

2025-08-06
Recruiting→Active, Not Recruiting Study Identification, Study Status, Study Description, Outcome Measures, Eligibility, Contacts/Locations v3
Trial statusRecruiting→Active, Not Recruiting
Primary completion date2025-07-31→2025-11-30
Completion date2025-07-31→2025-11-30
Eligibility criteria+395 characters
[...] ary artery disease, defined as left main stem >50% stenosis and/or ≥ moderate disease in ≥3 major epicardial vessels requiring revascularisation. Unstable angina New York Heart Association class III/IV hea [...] , deep vein thrombosis, stroke or transient ischaemic attack (<6 months) Severe autonomic or peripheral neuropathy Acute systemic illness of fever Significant acute or chronic renal failure that would preclude contrast use at CT PulmonarySignificant pulmonary fibrosis or interstitial lung disease (as assessed by a pulmonary physician) Physically unable to participate in high-intensity exercis [...] [...]
Secondary endpoints24 to 21 entries
Freedom from AF at 12-months Change in% burden of AF Duration and number of AF episodes Time to first arrhythmia recurrence ChangeAnthropometrics - Body weight Visceral fat Cardiac structural and functional assessment with echocardiography CTCA based changes in stroke risk - defined by Atriomic Stroke Algorithm Change in stroke risk - defined by CHA₂DS₂-VASc Change inleft atrial fibrillationstructure Serum symptoms,lipid aslevels Glucose definedcontrol by(HbA1c) Inflammatory themarker (high-sensitivity C-reactive protein) Physical activity European Heart Rhythm Association (EHRA) AF-score Chan [...] [...]
Primary endpoints1 entry, revised
DifferenceSymptom in symptomsburden, as defined by the University of Toronto Atrial Fibrillation Severity Scale (AFSS)
Study description-44 characters
[...] ed symptomatic AF such that their treating team have elected for a rhythm-control strategy (i.e. a combination of anti-arrhy [...] change in AF burden (i.e. the amount of time spent in AF), stroke risk, quality-of-life and well-being, biochemical, anthropometric, [...] blood pressure and cardiac functional and structural changes, and a cost-effectiveness analysis.
Study sitesdetails revised at 1 of 1 site
Study title-2 characters
Super-Rehab: a Novel Approach to ReverseTreat Atrial Fibrillation
2025-04-03
Study Identification, Study Status, Study Design v2
PhasePhase 3→Not applicable
2023-09-07
Not Yet Recruiting→Recruiting Study Status, Contacts/Locations v1
Trial statusNot Yet Recruiting→Recruiting
Primary completion date2024-11-01→2025-07-31
Completion date2024-11-01→2025-07-31
Start dateestimated 2022-11-01→confirmed 2023-04-03
Study sitesdetails revised at 1 of 1 site
2022-10-26
Original filing
This study proposes to evaluate the effectiveness of a novel lifestyle intervention (Super Rehab), in addition to standard care, for patients with symptomatic atrial fibrillation (AF) requiring rhythm control strategy who are overweight. As the main driver behind the selection of a rhythm-control strategy for patients with AF, the primary outcome will be an improvement in AF-related symptoms with Super Rehab versus Usual Care only. Secondary outcomes will include the burden of AF, biochemical and cardiac functional and structural changes, and markers of quality-of-life and health resource use.
Trial Details
NCT Number NCT05596175
Lead Sponsor Royal United Hospitals Bath NHS Foundation Trust
Collaborators: University of Bath, University of Oxford, Biotronik SE & Co. KG, RUHX (Official NHS Charity for RUH Bath)
Conditions Atrial Fibrillation, Overweight and Obesity
Enrollment 36 participants
Start Date 2023-04-03
Primary Completion 2025-11-30 (estimated)
Study Completion 2025-11-30 (estimated)
Updated on ClinicalTrials.gov 2025-08-12