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Tnf Inhibitors to Reduce Mortality in HIV-1 Infected PAtients With Tuberculosis meNIngitis

Study acronym: TIMPANI
StatusRecruiting
PhasePhase 2
Started
View on ClinicalTrials.gov ↗

Record History

See every version on ClinicalTrials.gov ↗

  1. Primary completion date: Dec 2026 to Jun 2027
    • Study completion date: Jun 2027 to Dec 2027
    • Eligibility criteria shortened, about 27 words
    • Secondary endpoints: 16 to 18
    v5
  2. Primary completion date: Jun 2025 to Dec 2026
    • Study completion date: Dec 2025 to Jun 2027
    v4
  3. Trial status: Not Yet Recruiting to Recruitingv3 Show 4 more changesShow less
    • Primary completion date: Sep 2024 to Jun 2025
    • Study completion date: Mar 2025 to Dec 2025
    • Start date changed from estimate of Feb 15, 2023 to Apr 11, 2023
    • Site details revised at 3 of 3 sites
  4. Start date: Dec 15, 2022 to Feb 15, 2023v2
  5. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Randomized phase II clinical trial which aims to assess the impact on 3-month mortality and safety of adding adalimumab to standard treatment (anti-tuberculosis drugs and corticosteroids) in HIV patients with tuberculosis meningitis in 3 countries (Brazil, Mozambique, and Zambia).
Trial Details
NCT Number NCT05590455
Lead Sponsor ANRS, Emerging Infectious Diseases
Conditions
(from sponsor)		 Tuberculous Meningitis, HIV I Infection
Related terms Tuberculosis, Meningeal
Enrollment 130 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov