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Decolonization to Reduce After-Surgery Events of Surgical Site Infection

Study acronym: DECREASE SSI
StatusRecruiting
PhasePhase 4
Started
View on ClinicalTrials.gov ↗

Record History

  1. Primary completion date: Jan 2027 to Jun 2027 Completion date: Dec 2028 to Dec 2027v8 Show 1 more changeShow less
    • Completion date: Dec 2028 to Dec 2027
  2. Primary completion date: Dec 2027 to Jan 2027 Site contacts updated at 1 of 4 sitesv7 Show 1 more changeShow less
    • Site contacts updated at 1 of 4 sites
  3. Study sites: 3 to 4 Collaborators: 3 to 4v6 Show 1 more changeShow less
    • Collaborators: 3 to 4

    See this version in full on ClinicalTrials.gov ↗

  4. Eligibility criteria shortened, about 7 wordsv5 See this version in full on ClinicalTrials.gov ↗
  5. Eligibility criteria expanded, about 9 wordsv4 See this version in full on ClinicalTrials.gov ↗
Show 2 earlier versionsHide 2 earlier versions
  1. Trial status: Not Yet Recruiting to Recruiting Start date changed from estimate of Jan 2023 to Jan 17, 2023 · Eligibility criteria expanded, about 38 words · Site details revised at 3 of 3 sitesv3 Show 3 more changesShow less
    • Start date changed from estimate of Jan 2023 to Jan 17, 2023
    • Eligibility criteria expanded, about 38 words
    • Site details revised at 3 of 3 sites

    See this version in full on ClinicalTrials.gov ↗

  2. Eligibility criteria expanded, about 9 wordsv2 See this version in full on ClinicalTrials.gov ↗
  1. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The DECREASE SSI Trial (Decolonization to Reduce After-Surgery Events of Surgical Site Infection) is a two-arm multi-center individual placebo-controlled randomized (2,700 participants randomized 1:1) clinical trial to reduce post-discharge surgical site infection following open colon or small bowel surgery by comparing chlorhexidine bathing plus nasal mupirocin in the 30 days following discharge to soap without antiseptic properties (placebo) and placebo nasal ointment. This trial seeks to enhance the care of the 675,000 patients annually who undergo colon and small bowel surgery by finding simple and efficacious interventions to reduce SSI.
Trial Details
NCT Number NCT05586776
Lead Sponsor University of California, Irvine
Collaborators: University of California, Davis, University of California, San Francisco, University of Massachusetts, Amherst, Hoag Memorial Hospital Presbyterian
Conditions Surgical Site Infection
Enrollment 2,700 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov