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Linking Brain Network Dynamics to Imminent Smoking Lapse Risk and Behavior

StatusRecruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗

Record History

  1. Primary completion date: Mar 2027 to Jul 2027v6
  2. Site contact updatedv5
  3. Start date: Jan 4, 2023 to Apr 4, 2023v4
  4. Start date: Apr 4, 2023 to Jan 4, 2023 Eligibility criteria shortened, about 31 wordsv3 Show 1 more changeShow less
    • Eligibility criteria shortened, about 31 words

    See this version in full on ClinicalTrials.gov ↗

  5. Trial status: Not Yet Recruiting to Recruiting Start date changed from estimate of Dec 2022 to Apr 4, 2023 · Site details revisedv2 Show 2 more changesShow less
    • Start date changed from estimate of Dec 2022 to Apr 4, 2023
    • Site details revised
  6. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Most attempts to quit smoking end in relapse, or a return to regular smoking. One of the biggest threats to cessation is a lapse (i.e., any cigarette use during a quit attempt). Thus, characterizing why lapses occur is essential to understanding and preventing smoking relapse. Functional magnetic resonance imaging (fMRI) is a promising method for characterizing the psychological processes that lead to smoking lapses because it provides a way to measures patterns of brain activity thought to reflect relevant mental processes as they change over time. However, methodological issues have hindered the ability to capitalize on this potential and prevented an understanding of how brain activity and corresponding psychological processes unfold in the critical moments that immediately precede a smoking lapse. The proposed project will address this knowledge gap using a novel fMRI paradigm adapted from a well-validated behavioral lapse task. The goals of the project are to characterize changes in brain activity that lead up to a lapse and to investigate how these changes are related to concurrent affect and subsequent cigarette use.
Trial Details
NCT Number NCT05572671
Lead Sponsor Penn State University
Conditions Smoking, Tobacco Use
Enrollment 150 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov