Clinical Trial

Applying pGz in Mitochondrial Disease

Recruiting Phase 1
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Summary
This is a multi-aim study, studying the effects of conventional exercise (measured through Cardiopulomary Exercises Testing or an in-bed pedal exercise) and passive exercise through periodic acceleration (pGz). Aim 1 will focus on the differences between primary mitochondrial disease (PMD) patients and healthy volunteers. Aim 2 is an exploratory aim, which will be studying the effects in patients admitted to the Children's Hospital of Philadelphia Pediatric Intensive Care Unit (PICU).
Protocol Amendment History 7 amendments
This ClinicalTrials.gov record has been amended 7 times since 2022-10-03; most recent amendment 2025-11-05.
Status change: Not Yet Recruiting → Recruiting 2023-05-18
Trial Details
NCT Number NCT05569122
Lead Sponsor Children's Hospital of Philadelphia
Collaborators: United States Department of Defense
Conditions Mitochondrial Myopathies, Mitochondrial Diseases
Enrollment 90 participants
Start Date 2023-03-22
Primary Completion 2027-09 (estimated)
Study Completion 2028-09 (estimated)
Updated on ClinicalTrials.gov 2025-11-10