RCT of Implantable Defibrillators in Patients With Non Ischemic Cardiomyopathy, Scar and Severe Systolic Heart Failure

BRITISH is a UK multicentre trial of patients who have been diagnosed with heart failure due to Non-Ischemic Cardiomyopathy (NICM, or heart failure that is not caused by blocked heart arteries. Participants will be randomised into two groups. Half the participants will receive an Implantable Cardioverter-Defibrillator (ICD) and the other half will not. The aim of the study will be to compare all-cause mortality (death from any cause) between these two groups at 36 months, and longer-term to 10 years. The study has the potential to change international heart failure treatment guidelines and to improve how patients with this condition are managed.

NCT Number	NCT05568069
Lead Sponsor	University Hospital Southampton NHS Foundation Trust Collaborators: British Heart Foundation, University of Southampton
Conditions	Heart Failure
Enrollment	2,504 participants
Start Date	2023-04-12
Primary Completion	2029-02-28 (estimated)
Study Completion	2032-02-28 (estimated)
Updated on ClinicalTrials.gov	2026-06-16