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The Effect of Physical Activity on Postural Orthostatic Tachycardia Syndrome

Study acronym: POTS
StatusRecruiting
PhaseNot applicable
Started
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Record History

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  1. 2 versions Re-verified since May 26, 2025, no change to tracked fieldsv7-v8
  2. Primary completion date: Mar 2027 to Mar 2028
    • Study completion date: Oct 2027 to Oct 2028
    v6
  3. Primary completion date: Oct 2024 to Mar 2027
    • Study completion date: Nov 2024 to Oct 2027
    v5
  4. Trial status: Active, Not Recruiting to Recruiting
    • Enrollment target: 8 to 200
    • Site details revised
    v4
  5. Enrollment target: estimated 200 to confirmed 8
    • Trial status: Recruiting to Active, Not Recruiting
    • Site details revised
    v3
  6. Trial status: Not Yet Recruiting to Recruitingv2 Show 4 more changesShow less
    • Study sites: 0 to 1
    • Start date changed from estimate of Oct 2022 to Nov 2, 2022
    • Secondary endpoints: details revised at 2 of 4 entries
    • Publications: 5 to 8
  7. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Postural orthostatic tachycardia syndrome (POTS) is a disorder of unknown origin characterized by orthostatic intolerance and increased heart rate (HR) of ≥ 30 beats/minute during orthostasis in the absence of orthostatic hypotension. In addition to the orthostatic intolerance and tachycardia, patients with POTS experience several debilitating symptoms including light-headedness, nausea, blurred vision, fatigue, mental confusion ("brain-fog"), chest pain and gastrointestinal problems. Several potential underlying mechanisms have been suggested for POTS including autonomic denervation, hypovolemia, hyperadrenergic stimulation and autoantibodies against adrenergic receptors. However, none of these proposed mechanisms has yet led to an effective treatment. Physical activity is recommended as a complimentary treatment in POTS in international guidelines. However, less is known regarding how physical activity could successfully be implemented in clinical practice in patients with POTS. Thus, in the current study, we aim to assess the effect of a 16-week specialized physical activity program in POTS.
Trial Details
NCT Number NCT05554107
Lead Sponsor Lund University
Collaborators: Region Skane
Conditions
(from sponsor)		 POTS - Postural Orthostatic Tachycardia Syndrome
Related terms Motor Activity, Orthostatic Intolerance, Postural Orthostatic Tachycardia Syndrome
Enrollment 200 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov