Choice of Anesthesia in Microelectrode Recording Guided Deep Brain Stimulation for Parkinson's Disease

Subthalamic nucleus (STN)-deep brain stimulation (DBS) under general anesthesia has been applied to PD patients who cannot tolerate awake surgery, but general anesthesia will affect the electrical signal in microelectrode recording (MER) to some degree. This study is a prospective randomized controlled, noninferiority study, open label, endpoint outcome evaluator blinded, two-arm study. Parkinson's disease patients undergoing STN-DBS are randomly divided into a conscious sedation group (dexmedetomidine) and a general anesthesia group (desflurane). Normalized root mean square (NRMS) is used to compare the difference of neuronal activity between the two groups. The primary outcome is the percentage of high NRMS recorded by the MER signal (with the average NRMS recorded by MER after entering the STN greater than 2.0). The secondary outcomes are the NRMS, length of the STN, number of MER tracks, and differences in clinical outcomes 6 months after the operation.

NCT Number	NCT05550714
Lead Sponsor	Beijing Tiantan Hospital
Conditions	PD - Parkinson's Disease, Dexmedetomidine, Desflurane, Deep Brain Stimulation
Enrollment	188 participants
Start Date	2022-10-15
Primary Completion	2024-03-26 (estimated)
Study Completion	2024-09-30 (estimated)
Updated on ClinicalTrials.gov	2024-08-01