Multi-Center Molecular Diagnosis and Host Response of Respiratory Viral Infections in Pediatric Transplant Recipients

The participants are being asked to take part in this clinical trial, a type of research study, because the participants are scheduled to receive or have recently received a hematopoietic cell transplant (HCT) or a solid organ transplant (SOT). Primary Objective To determine if pre-transplant screening for respiratory viral load predicts RVI within 1- year post-transplant among survivors. Secondary Objectives: * To develop and validate a classifier based on pre-transplant immunological profile predictive of developing an acute respiratory viral infection (aRVI), with RSV/PIV3/HMPV/SARS-CoV-2 through one-year post-transplant among survivors. * To develop and validate a classifier based on Day +100 post-transplant immunological profiles predictive of developing an acute respiratory viral infection (aRVI),with RSV/PIV3/HMPV/SARS-CoV-2 through one-year post-transplant among survivors .

NCT Number	NCT05550298
Lead Sponsor	Arkansas Children's Hospital Research Institute Collaborators: St. Jude Children's Research Hospital, Seattle Children's Hospital, Children's Hospital at Montefiore, National Institute of Allergy and Infectious Diseases (NIAID)
Conditions	Hematopoietic Cell Transplant, Solid Organ Transplant, Respiratory Viral Infection
Enrollment	2,000 participants
Start Date	2022-12-13
Primary Completion	2027-08 (estimated)
Study Completion	2029-08 (estimated)
Updated on ClinicalTrials.gov	2025-10-02