Change of Hemodynamics and Cerebral Functions After Carotid Artery Revascularization

The majority (\>80%) of strokes are of ischemic etiology, of which ≈15% to 20% are attributable to atherosclerosis of the extracranial carotid arteries. The primary goal in carotid artery revascularization is to prevent stroke in patients with carotid artery stenosis. Treatment options including carotid endarterectomy (CEA) and carotid artery stenting (CAS). Hence, the investigators aim to compare carotid artery stenting (CAS) with carotid endarterectomy (CEA) in terms of long-term prognostic endpoints. Also, CEA and CAS result in different postoperative geometric features of carotid arteries that entail relevant modifications of rheological parameters, that may be associated with the risk of local complications and carotid artery restenosis. Finally, long-term and sustained cognitive benefits after carotid artery revascularization need further research and evidence.

NCT Number	NCT05539781
Lead Sponsor	Beijing Friendship Hospital
Conditions	Carotid Artery Diseases, Carotid Artery Stenosis, Cerebrovascular; Disorder, Arteriosclerotic, Cardiovascular Diseases, Nervous System Diseases
Enrollment	200 participants
Start Date	2020-01-01
Primary Completion	2024-12-31 (estimated)
Study Completion	2026-12-31 (estimated)
Updated on ClinicalTrials.gov	2022-09-14