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A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid Tumors

StatusActive, Not Recruiting
PhasePhase 1
SponsorPfizer
Started2022-11-30
View on ClinicalTrials.gov ↗
The purpose of this clinical trial is to learn the safety and effects of the study medicine (PF-07799544) alone or in combination as a potential cancer treatment for adults with advanced solid tumors. The study will be conducted in two parts: PF-07799544 as a single agent (Phase 1a) and PF-07799544 in combination with another study medicine called PF-07799933 (Phase 1b). Phase 1a is no longer open for enrollment. In Phase1b (noted as "this study"), we are seeking participants who have: * a solid tumor which is metastatic or recurrent (excluding colorectal cancer) * tumor with the mutation (abnormal gene) called "BRAF V600" * received required prior treatment for cancer per cohort assigned. All participants in this study will receive both study medicines. Both study medicines are tablets that are taken by mouth at home twice a day. Participants will receive study medicines until their cancer is no longer responding, unacceptable side effects, or 2 years. Participants may continue to receive study therapy beyond 2 years. We will examine the experiences of people receiving the study medicines. This will help us determine if the study medicines are safe and effective.

Amendment history 9 changes detected by DataLookout

2026-09-02
notable
Enrollment closed, study ongoing
2026-09-02
minor
Final enrollment: 148 participants (planned 124)
2026-09-02
minor
Trial sites reduced: 83 → 66 locations
2026-09-02
minor
Completion moved earlier: 2029-06-18 → 2027-08-31
2026-06-06
minor
Completion pushed: 2029-02-07 → 2029-06-18
2026-05-12
minor
Trial sites expanded: 39 → 79 locations
2026-05-06
minor
Trial sites reduced: 77 → 39 locations
2026-04-24
notable
Primary completion pushed: 2027-05-26 → 2027-08-09
2026-04-24
minor
Completion pushed: 2028-11-24 → 2029-02-07
Trial Details
NCT Number NCT05538130
Lead Sponsor Pfizer
Conditions Melanoma, Glioma, Thyroid Cancer, Non-Small Cell Lung Cancer, Malignant Neoplasms, Brain Neoplasms, Advanced or Metastatic Solid Tumors, HGG +5 more
Enrollment 148 participants
Start Date 2022-11-30
Primary Completion 2027-08-31 (estimated)
Study Completion 2027-08-31 (estimated)
Updated on ClinicalTrials.gov 2026-09-01