Human Intracranial Electrophysiology

This study will enroll patients with epilepsy who are being evaluated for epilepsy surgery and have electrodes implanted in the brain and/or have electrodes on the scalp. Additionally, this study will recruit normal and online controls (participants who do not have epilepsy). Participants will be asked to participate in 1 to 2 (30-90 minutes) daily sessions designed to test aspects of human cognition such as memory, speech, language, feeling, movement, attention, sound perception, and emotions. Generally, this will involve working on a computer, looking at pictures or watching videos, and answering questions. Additionally, participants may be asked to be hooked up to additional equipment such as eye tracker, electrical stimulator, heart rate monitor, sweat monitor or other non-invasive equipment. The overall aim of this study is to use human intracranial electrophysiology (the recording of the electrical activity of the human brain) to study localization and function of the human brain.

NCT Number	NCT05529264
Lead Sponsor	Dartmouth-Hitchcock Medical Center Collaborators: Dartmouth College
Conditions	Epilepsy
Enrollment	175 participants
Start Date	2023-01-17
Primary Completion	2027-08-01 (estimated)
Study Completion	2032-08-01 (estimated)
Updated on ClinicalTrials.gov	2026-01-15