Clinical Trial

Watchful Waiting for Complete Responders to Therapy in Rectal Cancer

Terminated
View on ClinicalTrials.gov →
Why the trial stopped
Lack of financial support
Summary
The purpose of this project is to determine if in a selected group of patients, at higher risk of wound dehiscence and other complications, treatment by local excision and management by a "watchful waiting" or an initial "non-operative management" approach, with an offer of radical resection only to those patients whose tumors demonstrate "regrowth" will maintain acceptable local control and overall survival rate for the whole cohort.
Protocol Amendment History 5 changes
critical Trial terminated 2026-07-24
critical Phase changed: Phase 2 -> not applicable 2026-07-24
notable Enrollment reduced: 30 -> 15 participants 2026-07-24
notable Primary completion moved earlier: 2028-07-09 -> 2026-03-31 2026-07-24
minor Completion moved earlier: 2029-07-09 -> 2026-03-31 2026-07-24
Trial Details
NCT Number NCT05526079
Lead Sponsor Henry Ford Health System
Conditions Rectal Cancer
Enrollment 15 participants
Start Date 2018-07-10
Primary Completion 2026-03-31 (estimated)
Study Completion 2026-03-31 (estimated)
Updated on ClinicalTrials.gov 2026-07-23