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Noninvasive Brain Stimulation to Enhance Reading Comprehension Ability in Adults

StatusRecruiting
PhaseNot applicable
Started
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Record status
This record was last updated August 1, 2025 (before its estimated September 10, 2026 completion). Its status may not reflect the trial's current state.

Record History

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  1. Enrollment target: 225 to 100v5 Show 6 more changesShow less
    • Primary completion date: Aug 31, 2025 to Sep 10, 2026
    • Study completion date: Aug 31, 2026 to Sep 10, 2026
    • Interventions: CCN real non-invasive brain stimulation intervention (Device), RLN and CCN real non-invasive brain stimulation intervention (Device), RLN… to RLN and CCN real non-invasive brain stimulation intervention (Device), RLN real non-invasive brain stimulation intervention (Device), Sham…
    • Eligibility criteria expanded, about 57 words
    • Study description revised
    • Study arms: 4 to 3
  2. Re-verified, no change to tracked fieldsv4
  3. Eligibility criteria expanded, about 21 words
    • Study description expanded, about 642 words
    v3
  4. Trial status: Not Yet Recruiting to Recruiting
    • Primary completion date: Aug 31, 2026 to Aug 31, 2025
    • Start date changed from estimate of Dec 15, 2022 to Nov 7, 2022
    • Site details revised
    v2
  5. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The goal of this project is to address the urgent need for effective, scalable adult literacy interventions by integrating breakthroughs in two separate fields: 1.) the brain network science of resilience to reading disorders and 2.) high-definition non-invasive brain network stimulation. This study will first establish the efficacy of a novel, noninvasive stimulation protocol on reading behavior and brain metrics; then will determine how stimulation-induced effects interact with baseline reading comprehension ability; and lastly, will identify whether stimulation-induced effects are more clinically-beneficial than canonical behavioral interventions. Results may change the foundation for how we treat low adult literacy, and have the potential for wider reaching impacts on non-invasive stimulation protocols for other clinical disorders.
Trial Details
NCT Number NCT05523505
Lead Sponsor Vanderbilt University
Collaborators: National Institutes of Health (NIH)
Conditions
(from sponsor)		 Reading Disability
Related terms Dyslexia
Enrollment 100 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov