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Overcoming Nicotine Dependence to Enable Quitting

Study acronym: ON-DEQ
StatusRecruiting
PhasePhase 1/2
Started
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Record History

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  1. Minor 2 versions Re-verified since Aug 13, 2025, no change to tracked fieldsv6-v7
  2. Notable Start date: Feb 1, 2023 to Mar 24, 2023
    • Primary and study completion dates: May 30, 2027 to Aug 30, 2027
    v5
  3. Minor Primary and study completion dates: Aug 30, 2027 to May 30, 2027
    • Start date: Mar 1, 2023 to Feb 1, 2023
    v4
  4. Minor Study title shortened, about 4 wordsv3
  5. Notable Trial status: Not Yet Recruiting to Recruiting
    • Eligibility criteria expanded, about 30 words
    • Site details revised
    v2
  6. Minor Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Tobacco use disorder is a chronic, relapsing health condition that necessitates a chronic care approach. However, traditional smoking cessation treatment programs allocate nearly all their resources only to those smokers who are willing to set a quit date. This is problematic because few smokers are ready to set a quit date at any given time, and a smoker's stated intention to quit can change rapidly. One novel potential treatment strategy is to foster practice quitting (PQ), defined as attempting to not smoke for a few hours or days, without pressure or expectation to permanently quit. Although a growing body of evidence supports the role of practice quitting in fostering permanent quit attempts and cessation, there is a significant knowledge gap regarding which treatment strategies should be used to engage smokers in practice quitting. The proposed study will test the role of PQ counseling vs. Motivational Interviewing (MI) counseling, and NRT sampling (four-week supply of nicotine lozenges and patches) vs. none.
Trial Details
NCT Number NCT05513872
Lead Sponsor Rush University Medical Center
Collaborators: Medical University of South Carolina
Conditions
(from sponsor)
Tobacco Use, Smoking Cessation, Smoking Behaviors, Nicotine Dependence, Nicotine Withdrawal
Related terms Smoking, Smoking Cessation, Tobacco Use, Tobacco Use Disorder
Enrollment 780 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov