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Naltrexone Neuroimaging in Teens With Eating Disorders

Study acronym: NN-RCT
StatusRecruiting
PhaseEarly Phase 1
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated November 25, 2025 (before its estimated September 2026 completion). Its status may not reflect the trial's current state.

Record History

See every version on ClinicalTrials.gov ↗

  1. Site contact updatedv7
  2. Site contact updated
    • Collaborators: 1 to 2
    v6
  3. Collaborators expanded, about 5 wordsv5
  4. Site contact updatedv4
  5. Trial status: Not Yet Recruiting to Recruiting
    • Start date changed from estimate of Sep 2022 to Sep 17, 2022
    • Site details revised
    v3
  6. Eligibility criteria expanded, about 13 words
    • Study description expanded, about 12 words
    • Study title expanded, about 2 words
    v2
  7. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Using a randomized, placebo-controlled, crossover study, this study will evaluate functional magnetic resonance imaging (fMRI) as a pharmacodynamic biomarker of opioid antagonism in adolescents with eating disorders. The hypothesis is that fMRI will be able to detect acute reward pathway modulation by naltrexone (an opioid antagonist) in pre-defined regions of interest (anterior cingulate cortex, nucleus accumbens, dorsolateral prefrontal cortex).
Trial Details
NCT Number NCT05509257
Lead Sponsor Children's Mercy Hospital Kansas City
Collaborators: University of Kansas Medical Center, National Institute of Mental Health (NIMH)
Conditions
(from sponsor)		 Eating Disorders, Binge Eating, Purging (Eating Disorders), Bulimia Nervosa, Anorexia Nervosa, Atypical
Related terms Anorexia Nervosa, Bulimia, Bulimia Nervosa, Feeding and Eating Disorders
Enrollment 60 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov