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NCT05507138 · ClinicalTrials.gov record · last posted 2026-08-20

A Digital Intervention for Post-Stroke Depression and Executive Dysfunction

StatusRecruiting
PhasePhase 2
Started2023-03-01
View on ClinicalTrials.gov ↗
from the ClinicalTrials.gov record
Individuals with stroke commonly experience both depression and cognitive difficulties. The goal of this study is to evaluate the efficacy of a treatment that combines a digital therapeutic (an iPad-based cognitive training program) with learning cognitive strategies. The hypotheses are that this treatment will improve cognitive skills, depression symptoms, daily function, and brain connectivity. In the short-term, the findings will inform the efficacy of the intervention and in the long-term, may support the use of the intervention to improve co-occurring cognitive and mood difficulties after stroke.

Protocol amendment history 2 changes detected by DataLookout

2026-08-21
critical
Primary completion pushed: 2026-06-30 → 2027-06-30
2026-08-21
minor
Completion pushed: 2026-09-30 → 2027-09-30
Trial Details
NCT Number NCT05507138
Lead Sponsor Weill Medical College of Cornell University
Collaborators: National Institute of Mental Health (NIMH)
Conditions Executive Dysfunction, Depression, Stroke
Enrollment 70 participants
Start Date 2023-03-01
Primary Completion 2027-06-30 (estimated)
Study Completion 2027-09-30 (estimated)
Updated on ClinicalTrials.gov 2026-08-20