Ketone Supplementation in Eating Disorders

This study will investigate the effects of ketone supplementation on eating behavior including drive to binge eat or restrict, mood and anxiety in individuals with anorexia or bulimia nervosa. In addition, the investigators will contrast the effects of active ketone supplementation versus placebo on electroencephalogram (EEG) measurement. All subjects enrolled in the study will undergo EEG on two consecutive days at the beginning of the study, after active ketone supplementation or placebo drink, matched in taste to the ketone drink. Days will be randomized. Thereafter, all subjects will take the ketone supplementation drink for two weeks, twice daily.

NCT Number	NCT05507008
Lead Sponsor	University of California, San Diego
Conditions	Anorexia Nervosa, Bulimia Nervosa, Atypical Anorexia Nervosa, Atypical Bulimia Nervosa
Enrollment	38 participants
Start Date	2022-10-13
Primary Completion	2026-07-06 (estimated)
Study Completion	2026-07-06 (estimated)
Updated on ClinicalTrials.gov	2026-08-03