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Neuropsychological Care for Maintaining Quality of Life After Radiation Therapy in Patients With Brain Metastases

StatusActive, Not Recruiting
PhasePhase 2
Started2022-08-30
View on ClinicalTrials.gov ↗
Record status
This record was last updated December 24, 2025 (before its estimated June 28, 2026 completion). Its status may not reflect the trial's current state.

Amendment history

2025-12-18
Study Status, Oversight v5
Primary completion date2025-10-28→2026-06-28
Completion date2025-12-31→2026-06-28
2025-07-08
Study Status, Study Design v4
PhaseNot applicable→Phase 2
Primary completion date2025-04-28→2025-10-28
Completion date2025-08-30→2025-12-31
2025-02-06
Recruiting→Active, Not Recruiting Study Status, Oversight, Study Design, Contacts/Locations v3
Trial statusRecruiting→Active, Not Recruiting
Primary completion date2024-12-31→2025-04-28
Completion date2025-12-31→2025-08-30
Enrollment targetestimated 47→confirmed 110
Study sitesdetails revised at 1 of 1 site
2022-11-18
Not Yet Recruiting→Recruiting Study Status, Study Design, Contacts/Locations v2
Trial statusNot Yet Recruiting→Recruiting
PhasePhase 2→Not applicable
Start dateestimated 2022-10-31→confirmed 2022-08-30
Study sitesdetails revised at 1 of 1 site
2022-08-31
Study Status, Eligibility v1
Eligibility criteria-7 characters
[...] will be treated with radiation therapy for brain metastases All lesions < 2 cm Primarily English-speaking patient Graded Prognostic Assessm [...] vival > 6 months) Exclusion Criteria: Patient received prior whole brain radiation therapy to the brain Patient has multiple sclerosis, Alzheimer's, dementia, or mental disability
2022-08-15
Original filing
This phase II trial studies the effect of neuropsychological evaluation and intervention in maintaining quality of life after radiation therapy in patients with cancer that has spread to the brain (metastases). Quality of life refers to the overall enjoyment of life. It holds varying meanings for different people and may evolve over time. For some individuals it implies autonomy, empowerment, capability, and choice; for others, security, social integration, or freedom from stress or illness. Neuropsychological evaluation is used to examine the cognitive (thinking) consequences of brain damage, brain disease, and severe mental illness. Deterioration of both quality of life and cognitive function is common when receiving radiation to the brain. Neuropsychological evaluation with a certified neuropsychologist may improve quality of life or cognitive function after radiation therapy.
Trial Details
NCT Number NCT05503251
Lead Sponsor Ohio State University Comprehensive Cancer Center
Conditions Metastatic Malignant Neoplasm in the Brain, Metastatic Malignant Solid Neoplasm
Enrollment 110 participants
Start Date 2022-08-30
Primary Completion 2026-06-28 (estimated)
Study Completion 2026-06-28 (estimated)
Updated on ClinicalTrials.gov 2025-12-24