Clinical Trial

Broad-spectrum Antibiotic Prophylaxis in Tumor and Infected Orthopedic Surgery

Study acronym: BAPTIST
Recruiting Phase 3
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Record status
This record was last updated December 2, 2024 (before its estimated December 12, 2024 completion). Its status may not reflect the trial's current state.
Summary
The perioperative antibiotic prophylaxis is evidence-based in orthopedic surgery. While its duration ranges from a single dose to three doses throughout the world, the choice of the prophylactic agents is undisputed. Worldwide, the surgeons use 1st or 2nd-generation cephalosporins (or vancomycin in some cases). However, there are particular clinical situation with a high risk of antibiotic-resistant surgical site infections (SSI); independently of the duration of adminis-tered prophylaxis. These resistant SSI's occur in contaminated wounds, or during surgery under current therapeutic antibiotics, and base on "selection" by antibiotics used for therapy or for prophylaxis.
Protocol Amendment History 4 amendments
This ClinicalTrials.gov record has been amended 4 times since 2022-08-12; most recent amendment 2024-11-28.
Status change: Not Yet Recruiting → Recruiting 2023-02-27
Trial Details
NCT Number NCT05502380
Lead Sponsor Balgrist University Hospital
Conditions Surgical Site Infection, Microbial Colonization, Antibiotic Resistant Infection
Enrollment 1,100 participants
Start Date 2022-09-15
Primary Completion 2024-12-12 (estimated)
Study Completion 2025-12-12 (estimated)
Updated on ClinicalTrials.gov 2024-12-02