Opioid-Free Pain Protocol After Shoulder Arthroplasty

This randomized, single blinded, clinical trial aims to investigate the efficacy of a multimodal pain control regimen for shoulder arthroplasty. Patients who receive a multimodal pain control regimen alone (study group) will be compared to patients who receive a multimodal pain control regimen plus a standard prescription of an opioid containing medication (comparison group). The primary outcome is average daily Numerical Rating Scale (NRS) pain score in the first 10 days after surgery. We hypothesize that there will be no significant difference in the primary outcome between the two groups.

NCT Number	NCT05488847
Lead Sponsor	Henry Ford Health System
Conditions	Shoulder Arthropathy, Shoulder Pain
Enrollment	83 participants
Start Date	2022-06-25
Primary Completion	2024-12-11 (estimated)
Study Completion	2026-09-01 (estimated)
Updated on ClinicalTrials.gov	2026-02-10