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The Impact of Mitochondrial Dysfunction on Human Bone Cell Metabolism and Remodelling

StatusActive, Not Recruiting
PhaseNot applicable
Started
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Record status
This record was last updated October 2, 2025 (before its estimated August 1, 2026 completion). Its status may not reflect the trial's current state.

Record History

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  1. Primary completion date: Aug 1, 2024 to Aug 1, 2026
    • Trial status: Recruiting to Active, Not Recruiting
    • Study completion date: Jan 1, 2025 to Dec 1, 2026
    • Site details revised
    v4
  2. Primary completion date: Aug 1, 2023 to Aug 1, 2024
    • Study completion date: Jan 1, 2024 to Jan 1, 2025
    v3
  3. Eligibility criteria expanded, about 7 wordsv2
  4. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Cell and mice studies suggest mitochondrial dysfunction may cause altered bone structure. Hypothesis: Decreased mitochondrial energy production affects bone cell development and activity negatively. Comparing humans with the mitochondrial DNA variant, m.3243A\>G, pathogenic variants in POLG or TWNK genes to healthy controls, the aim is to evaluate the effect of mitochondrial dysfunction on: 1: bone-cell development and -activity in bone marrow stem cells and blood. 2: bone cell metabolism including glucose consumption. 3: bone structure assessed by electron microscopy and μCT scans of bone biopsies.
Trial Details
NCT Number NCT05483738
Lead Sponsor Aalborg University Hospital
Collaborators: Odense University Hospital, University of Southern Denmark
Conditions
(from sponsor)		 Mitochondrial Diseases, Bone Remodeling Disorder
Related terms Mitochondrial Diseases
Enrollment 30 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov