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MinorEligibility criteria expanded, about 16 words
Minor8 versionsRe-verified since Jun 23, 2026, no change to tracked fieldsv848-v855
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MinorStudy Status, Study Description, Eligibilityv847
Minor12 versionsRe-verified since Mar 31, 2026, no change to tracked fieldsv835-v846
MinorStart date changed from estimate of Apr 2, 2026 to Mar 27, 2026v834
MinorStart date: Apr 1, 2026 to Apr 2, 2026v833
MinorStart date: Mar 31, 2026 to Apr 1, 2026v832
MinorStart date: Mar 30, 2026 to Mar 31, 2026v831
MinorStart date: Mar 29, 2026 to Mar 30, 2026v830
MinorStart date: Mar 26, 2026 to Mar 29, 2026v829
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MinorStart date: Mar 24, 2026 to Mar 25, 2026v827
MinorStart date: Mar 23, 2026 to Mar 24, 2026v826
MinorStart date: Mar 22, 2026 to Mar 23, 2026v825
MinorStart date: Mar 19, 2026 to Mar 22, 2026v824
MinorStart date: Mar 18, 2026 to Mar 19, 2026v823
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MinorStart date: Mar 16, 2026 to Mar 17, 2026v821
MinorStart date: Mar 15, 2026 to Mar 16, 2026v820
MinorStart date: Mar 12, 2026 to Mar 15, 2026v819
MinorStart date: Mar 11, 2026 to Mar 12, 2026v818
MinorStart date: Mar 10, 2026 to Mar 11, 2026v817
MinorStart date: Mar 9, 2026 to Mar 10, 2026v816
MinorStart date: Mar 8, 2026 to Mar 9, 2026v815
MinorStart date: Mar 5, 2026 to Mar 8, 2026v814
MinorStart date: Mar 4, 2026 to Mar 5, 2026v813
MinorStart date: Mar 3, 2026 to Mar 4, 2026v812
MinorStart date: Mar 2, 2026 to Mar 3, 2026v811
MinorStart date: Mar 1, 2026 to Mar 2, 2026v810
Stopped: an ongoing trial was terminated, suspended or withdrawn.
Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Background:
People with intellectual disability (ID) often have physical disabilities as well. These physical problems can affect their bones, muscles, nerves, and gastrointestinal tracts. All of these issues can also cause pain. Yet little research has been done on pain in people with ID.
Objective:
To compare brain responses to unpleasant stimuli in people with and without ID.
Eligibility:
People aged 8 to 30 years diagnosed with an ID. Healthy volunteers without an ID are also needed.
Design:
The study requires only 1 visit of up to 4 hours. Participants with ID may come for up to 5 shorter visits instead.
Participants will take a test to measure their level of ID. They will have a physical exam.
Both groups will answer questions about pain and how their bodies react to it. They will answer questions about how they respond to things they see, feel, hear, smell, and taste. They will answer questions about their social behaviors. Caregivers may answer questions if the participant cannot.
Both groups will have a test to measure their brain activity. Participants will wear a special cap, like a swim cap, with sensors and wires. Sensors to examine the heart will be placed on the skin of their chest with stickers. An elastic band will be placed around the middle of their body to measure how fast they are breathing. Sensors to measure sweat will be placed on two fingers.
Participants will have heat, cold, brushing, and mild electrical stimuli to different parts of their body. Participants will rank how each stimulus feels using a scale with numbers or a scale with faces.