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Activated CHARcoal in Poisoned Patient - Pilot Trial

Study acronym: CHARPP-Pilot
StatusRecruiting
PhasePhase 4
Started
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Record status
This record was last updated January 29, 2026 (before its estimated June 1, 2026 completion). Its status may not reflect the trial's current state.

Record History

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  1. Notable Trial status: Not Yet Recruiting to Recruiting
    • Start date changed from estimate of May 1, 2025 to Jul 16, 2025
    • Site details revised
    v4
  2. Notable Start date: Feb 1, 2025 to May 1, 2025v3
  3. Notable Enrollment target: 850 to 100v2 Show 11 more changesShow less
    • Primary completion date: Jun 1, 2024 to Jun 1, 2026
    • Start date: Jun 1, 2023 to Feb 1, 2025
    • Study sites: 0 to 1
    • Study completion date: Dec 1, 2024 to Feb 1, 2027
    • Interventions: Activated Charcoal (Drug) to Activated Charcoal (Drug), No activated charcoal (Other)
    • Eligibility criteria expanded, about 44 words
    • Secondary endpoints revised (6)
    • Primary endpoints revised (3)
    • Study description expanded, about 592 words
    • Collaborators expanded, about 18 words
    • Study title expanded, about 3 words
  4. Minor Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The goal of this clinical pilot trial is to determine the feasibility of the clinical trial. Then the large-scale CHARPP will be conducted in order to determine the efficacity of activated charcoal as a treatment for acute poisoning in a diverse population of both adults and children suspected of ingesting toxic substances that activated charcoal can adsorb. The main questions it aims to answer are: * Can activated charcoal administered within a specific time frame prevent the progression of toxicity? * How does activated charcoal affect the length of stay in the hospital and the intensive care unit? Researchers will compare the intervention arm (receiving activated charcoal) to the control arm (receiving standard supportive care) to see if activated charcoal reduces hospital stay duration, ICU stay and improves overall patient outcomes. Participants will: * Be randomly assigned to either receive activated charcoal or standard supportive care. * Undergo assessments using standardized clinical scales such as the Poison Severity Score and, for children, the PELODS score. * Have their functional outcomes evaluated, such as the ability to return to their original residence without help and manage personal hygiene tasks independently. This structured approach will help clarify the role of activated charcoal in clinical toxicology and inform future treatment protocols.
Trial Details
NCT Number NCT05471479
Lead Sponsor Laval University
Collaborators: Canadian Institutes of Health Research (CIHR), VITAM - Centre de recherche en santé durable, CHU de Quebec-Universite Laval
Conditions
(from sponsor)
Charcoal, Decontamination, Poisoning
Related terms Anthrax, Poisoning
Enrollment 100 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov