Clinical Trial

Tranexamic Acid to Reduce Delirium After Gastrointestinal Surgery: the TRIGS-D Trial

Study acronym: TRIGS-D
Active, Not Recruiting Phase 3
View on ClinicalTrials.gov →
Record status
This record was last updated December 31, 2025 (before its estimated August 13, 2026 completion). Its status may not reflect the trial's current state.
Summary
Prophylactic TxA administration in patients undergoing major gastrointestinal surgery reduces the incidence of delirium after surgery when compared with placebo. The unifying hypothesis is that systemic and neuro-inflammation lead to neuronal injury and resultant postoperative delirium.
Protocol Amendment History 3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2022-07-20; most recent amendment 2025-12-29.
Status change: Recruiting → Active, Not Recruiting 2025-12-29
Status change: Not Yet Recruiting → Recruiting 2023-01-09
Trial Details
NCT Number NCT05470816
Lead Sponsor Bayside Health
Collaborators: Monash University
Conditions Surgical Site Infection, Dementia, Cognition
Enrollment 826 participants
Start Date 2022-11-01
Primary Completion 2026-08-13 (estimated)
Study Completion 2026-08-31 (estimated)
Updated on ClinicalTrials.gov 2025-12-31