MRI Study of Subjects with ASD, Their Relatives and TD

This project is structured around a central study called "Study of genetic factors involved in autism and related conditions ("Genes and Autism" study, sponsor: INSERM). This study explores clinical and genetic aspects of ASD (autism spectrum disorders) and is complemented with several ancillary studies (such as this one) which will use the data of the main study and will allow an extensive review of phenotypes associated with ASD. In this ancillary study, we will go on the acquisition of anatomical, diffusion and functional MRI in subjects with ASD, relatives and controls. Our group has already performed several neuroanatomical studies of ASD. IWe recruited since 2010 more than 600 subjects (proponents, relatives and controls) to better understand the implication of brain abnormalities in ASD. This study involves specialized teams in neuroiamging based at INSERM, NeuroSpin (CEA), Robert Debré Hospital (APHP) and Pasteur Institute Our main objective is to identify structural, connectivity and functional peculiarities in subjects with ASD Secondary objectives include: * the identification of familial heritability patterns of ASD * correlate data obtained in brain imaging with genetic data * assess specificity and statistical reproducibility of the obtained results

NCT Number	NCT05470088
Lead Sponsor	Institut National de la Santé Et de la Recherche Médicale, France Collaborators: APHP, Institut Pasteur, Commissariat A L'energie Atomique
Conditions	Autism Spectrum Disorder
Enrollment	1,000 participants
Start Date	2022-03-13
Primary Completion	2037-03-13 (estimated)
Study Completion	2039-09-13 (estimated)
Updated on ClinicalTrials.gov	2025-03-13