Use of CEST (Chemical Exchange Saturation Transfer) Imaging in PET/MRI

Standard Magnetic Resonance Imaging (MRI) is based on the excitation of hydrogen nuclei that are presents in water molecules, which abundance in human body allows for obtention of superior contrast. However, assessing the presence of other molecules than water in tissues is also of great clinical interest to probe metabolites related to physiological body function and pathological conditions. Chemical exchange saturation transfer (CEST) allow to overcome some limitations of proton magnetic resonance spectroscopy (1H-MRS) by exploiting chemical properties of the targeted molecule through a continuous process of re-saturation and exchange, and thus detecting it with increased sensitivity, from two orders of magnitude. Moreover, CEST technique is based on imaging sequences and can therefore benefit from well-known fast acquisition strategies, as well as improved spatial resolution.

NCT Number	NCT05464992
Lead Sponsor	Centre Paul Strauss
Conditions	Glioma, Brain Metastases
Enrollment	800 participants
Start Date	2022-12-28
Primary Completion	2036-12-28 (estimated)
Study Completion	2036-12-28 (estimated)
Updated on ClinicalTrials.gov	2026-02-02