Clinical Trial

Divided or Single Exposure (DOSE) Study

Name: Divided or Single Exposure (DOSE) Study — clinical trial record (NCT05459402)
Creator: DataLookout
License: https://creativecommons.org/licenses/by/4.0/

Recruiting Phase 2/3

View on ClinicalTrials.gov →

Summary

This study will evaluate whether once versus twice daily dosing of methadone will be an effective method for managing comorbid pain and opioid use disorder.

Protocol Amendment History 12 amendments

This ClinicalTrials.gov record has been amended 12 times since 2022-07-12; most recent amendment 2026-01-30.

Status change: Not Yet Recruiting → Recruiting 2023-03-07

Trial Details

NCT Number	NCT05459402
Lead Sponsor	University of Maryland, Baltimore Collaborators: National Institute on Drug Abuse (NIDA)
Conditions	Opioid Use Disorder, Chronic Pain, Methadone
Enrollment	150 participants
Start Date	2023-02-21
Primary Completion	2027-06-01 (estimated)
Study Completion	2028-06-01 (estimated)
Updated on ClinicalTrials.gov	2026-02-03