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Visualization of Inspiratory Effort and Respiratory Mechanics to Promote Lung- and Diaphragm Protective Ventilation

Study acronym: VIREM
StatusUnknown
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated April 6, 2025 (before its estimated June 30, 2025 completion). Its status may not reflect the trial's current state.

Record History

  1. Changed Registry marked status Unknown (sponsor has not verified the record since Sep 2024); last known: Recruiting
  2. Primary completion date: Apr 30, 2024 to Jun 30, 2025
    • Study completion date: Aug 1, 2024 to Dec 1, 2025
    • Site details revised at 2 of 3 sites
    v3
  3. Trial status: Not Yet Recruiting to Recruiting
    • Primary completion date: Jan 31, 2024 to Apr 30, 2024
    • Start date changed from estimate of Aug 1, 2022 to Sep 21, 2022
    • Site details revised at 3 of 3 sites
    v2
  4. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This is a multicentre prospective cohort trial in adult and pediatric ICU patients. The investigators will measure the effect of a patient's inspiratory effort during mechanical ventilation on the lungs and diaphragm. The investigators will daily (for a maximum of 8 days) measure esophageal pressures with a balloon catheter to quantify inspiratory effort and respiratory muscle function, and perform daily ultrasound measurements of the diaphragm and the lungs. The investigators hypothesize that a small inspiratory effort will result in the preservation of diaphragm function and have no adverse effect on lung function.
Trial Details
NCT Number NCT05459116
Lead Sponsor University Hospital, Antwerp
Collaborators: Research Foundation Flanders, Universitaire Ziekenhuizen KU Leuven, The Hospital for Sick Children, University of Toronto, Universiteit Antwerpen, KU Leuven
Conditions
(from sponsor)		 Respiratory Muscles, Respiration, Artificial, Respiratory Function Tests
Related terms Respiratory Aspiration
Enrollment 150 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov